BiG-SCAPE (Biosynthetic Gene Similarity Clustering and Prospecting Engine) is a Python software package that constructs sequence similarity networks of biosynthetic gene clusters (BGCs) and groups them into gene cluster families (GCFs).
BiG-SCAPE does this by rapidly calculating a distance matrix between gene clusters based on a comparison of their protein domain content, order, copy number, and sequence identity. Outputs of BiG-SCAPE are raw network files as well as a rich graphical user interface in HTML format that can be used to explore the networks and families in your browser.
CORASON (CORe Analysis of Syntenic Orthologs to prioritize Natural Product Biosynthetic Gene Clusters) is a visual tool that identifies gene clusters that share a common genomic core, and reconstructs multi-locus phylogenies of these gene clusters to explore their evolutionary relationships. CORASON outputs are newick trees, a core functional report and a graphical output in SVG format, displaying metadata such as gene function and genome coordinates, thus facilitating genomic analysis.
Learn more about CORASON in the CORASON wiki.
BiG-SCAPE and CORASON were developed in a collaboration between the research groups of Francisco (Paco) Barona-Gomez at Cinvestav (Mexico) and Marnix Medema at Wageningen University (The Netherlands). The development of these tools was lead by Jorge Navarro-Muñoz and Nelly Selem-Mojica, respectively.
For questions regarding CORASON, please contact Nelly and/or Paco. For questions regarding BiG-SCAPE, please go to the official repository (the Discussions or Issues sections), or contact Jorge and/or Marnix.